Amy Hsiao
Advisor: W.R. Curtis

Blood trauma is a major concern in the design of prosthetic heart devices. Damage can be caused by high stress such as turbulence, pressure, and physical contact. Certain additives such as dextran have been shown to reduce blood trauma by increasing viscosity. The overall objective of this project studies the effect of turbulence strength and viscosity on washed and resuspended red blood cells, and this thesis proposes a new device for this study. The existing batch reactor is incapable of further study because of limits in the flow regime it can achieve when viscosity is increased. The batch reactor is also inefficient because each experiment produces only one kinetic datum point. Construction of a continuous flow reactor overcomes many of these limitations. Based on a literary search of turbulence generating devices, a continuous-stirred tank was chosen for the design because it is widely studied and well defined. The proposed reactor meets two requirements: a smaller volume and turbulent flow in the desired range. The reactor has a volume of 26 mL, Rushton 6-blade impeller, and consists of an inner Teflon layer, an air gap, and an outer Aluminum housing. The negligible heat loss to the surrounding enables power consumption to be measured indirectly through an energy balance. In addition, the energy dissipation within the stirred fluid is large enough to generate a Kolmogorov length scale on the order of the cell diameter.